Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence?

Abdelrahim, Laila Mustafa and Peh, Suat Cheng and Kallarakkal, Thomas George (2018) Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? The Malaysian Journal of Pathology, 40 (1). pp. 49-56. ISSN 0126-8635

Full text not available from this repository.
Official URL: http://www.mjpath.org.my/2018/v40n1/Epstein-Barr-v...

Abstract

Introduction: Epstein–Barr virus (EBV) might be an aetiological agent involved in the pathogenesis of certain Non-Hodgkin’s Lymphomas (NHLs). EBV infection has been diagnosed by serologic testing within the tumour biopsies of patients with NHL. However, the association between EBV and NHL is inconsistent with a preference for certain anatomic sites, histologic subtypes and immunosuppressed patients. The objective of this study was to characterise the B-cell NHLs of the oral cavity and maxillofacial region using histological and immunophenotypical techniques and to determine its association with EBV infection. Materials and Methods: This was a descriptive cross-sectional study that included 14 cases of B-cell NHLs of the oral cavity and maxillofacial region. The haematopoietic and lymphoid tissue tumours classification of WHO was used to categorize the cases. In-situ hybridisation for EBV–encoded RNA was performed to confirm the EBV infection. Results: The average age of the patients included in the study was found to be 48.8 ± 23 years with a higher female to male ratio (1.3:1). Our study suggested that diffuse large B-cell lymphomas (DLBCLs) and Burkitt’s lymphomas (BLs) constitute the predominant subtypes of lymphomas affecting the oral cavity and maxillofacial regions. Conclusion: The findings from our study support the view that at least a relatively smaller proportion of B-cell NHLs that occur in the oral cavity and maxillofacial region do not have a pathogenic association with EBV.

Item Type: Article
Uncontrolled Keywords: B-cell NHL; Epstein–Barr virus; in-situ hybridisation; maxillofacialregion; oral cavity
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Oct 2019 08:57
Last Modified: 14 Oct 2019 08:57
URI: http://eprints.um.edu.my/id/eprint/22749

Actions (login required)

View Item View Item