Abdelrahim, Laila Mustafa and Peh, Suat Cheng and Kallarakkal, Thomas George (2018) Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? The Malaysian Journal of Pathology, 40 (1). pp. 49-56. ISSN 0126-8635, DOI PubMed ID: 29704384.
Full text not available from this repository.Abstract
Introduction: Epstein–Barr virus (EBV) might be an aetiological agent involved in the pathogenesis of certain Non-Hodgkin’s Lymphomas (NHLs). EBV infection has been diagnosed by serologic testing within the tumour biopsies of patients with NHL. However, the association between EBV and NHL is inconsistent with a preference for certain anatomic sites, histologic subtypes and immunosuppressed patients. The objective of this study was to characterise the B-cell NHLs of the oral cavity and maxillofacial region using histological and immunophenotypical techniques and to determine its association with EBV infection. Materials and Methods: This was a descriptive cross-sectional study that included 14 cases of B-cell NHLs of the oral cavity and maxillofacial region. The haematopoietic and lymphoid tissue tumours classification of WHO was used to categorize the cases. In-situ hybridisation for EBV–encoded RNA was performed to confirm the EBV infection. Results: The average age of the patients included in the study was found to be 48.8 ± 23 years with a higher female to male ratio (1.3:1). Our study suggested that diffuse large B-cell lymphomas (DLBCLs) and Burkitt’s lymphomas (BLs) constitute the predominant subtypes of lymphomas affecting the oral cavity and maxillofacial regions. Conclusion: The findings from our study support the view that at least a relatively smaller proportion of B-cell NHLs that occur in the oral cavity and maxillofacial region do not have a pathogenic association with EBV.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | B-cell NHL; Epstein–Barr virus; in-situ hybridisation; maxillofacialregion; oral cavity |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Oct 2019 08:57 |
| Last Modified: | 14 Oct 2019 08:57 |
| URI: | http://eprints.um.edu.my/id/eprint/22749 |
Actions (login required)
 |
View Item |
