A rare case of solitary unifocal Langerhans cell histiocytosis with orbital extension: Diagnostic dilemma

Addenan, Maftuhim and Choo, May May and Teoh, Kean Hooi and Ismail, Fazliana and Kamalden, Tengku Ain (2018) A rare case of solitary unifocal Langerhans cell histiocytosis with orbital extension: Diagnostic dilemma. Oman Journal of Ophthalmology, 11 (3). pp. 284-287. ISSN 0974-620X

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Official URL: https://doi.org/10.4103/ojo.OJO_149_2017

Abstract

Langerhans cell histiocytosis (LCH) is rarely encountered in ophthalmology practice. It is a spectrum of disorder characterized by accumulation of histiocytes in various tissues. Diagnosis is challenging as it may simulate periorbital hematoma, rhabdomyosarcoma, and neuroblastoma. We report a case of unifocal LCH with orbital extension. Diagnosis was obtained from incisional biopsy, and histopathological examination showed numerous histiocytes with eosinophilic infiltrations. The presence of Langerhans cells was confirmed by the presence of protein S-100, CD1a, and/or Langerin (CD207). Treatment depends on the degree of organ involvement. She responded well to cytotoxic drugs and steroids. This emphasized that prompt tissue diagnosis is crucial for early management.

Item Type: Article
Uncontrolled Keywords: Langerhans cell histiocytosis; orbit; uniforcal
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 08 Oct 2019 03:46
Last Modified: 08 Oct 2019 03:46
URI: http://eprints.um.edu.my/id/eprint/22704

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