Effect of pioglitazone on vasopressor responses to adrenergic agonists and angiotensin II in diabetic and non-diabetic spontaneously hypertensive rats

Afzal, Sheryar and Sattar, Munavvar Abdul and Akhtar, Safia and Abdullah, Nor Azizan and Eseyin, Olorunfemi A. and Abdulla, Mohammed H. and Johns, Edward James (2018) Effect of pioglitazone on vasopressor responses to adrenergic agonists and angiotensin II in diabetic and non-diabetic spontaneously hypertensive rats. Pakistan Journal of Pharmaceutical Sciences, 31 (3). pp. 747-754. ISSN 1011-601X

Full text not available from this repository.
Official URL: http://www.pjps.pk/wp-content/uploads/pdfs/31/3/Pa...

Abstract

Pioglitazone, peroxisome proliferator-activated receptor (PPAR-γ) agonist, is a therapeutic drug for diabetes. Present study investigated the interaction between PPAR-γ and alpha adrenoceptors in modulating vasopressor responses to Angiotensin II (Ang II) and adrenergic agonists, in diabetic & non-diabetic Spontaneously Hypertensive Rats (SHRs). Diabetes was induced with an i.p injection of streptozotocin (40 mg/kg) in two groups (STZ-CON, STZ-PIO), whereas two groups remained non diabetic (ND-CO, ND-PIO). One diabetic and non-diabetic group received Pioglitazone (10mg/kg) orally for 21 days. On day 28, the animals were anaesthetized with sodium pentobarbitone (60mg/kg) and prepared for measurement of systemic haemodynamics. Basal mean arterial pressure of STZ-CON was higher than ND-CON, whereas following pioglitazone treatment, MAP was lower compared to respective controls. MAP responses to i.v administration of NA, PE, ME and ANG II were significantly lower in diabetic SHRs: STZ-CON vs ND-CON (35%). Pioglitazone significantly decreased responses to NA, PE, ME and ANG II in ND-PIO versus ND-CON by 63%. Responses to NA and ANG II were significantly attenuated in STZ-PIO vs. ND-PIO (40%). PPAR-γ regulates systemic hemodynamic in diabetic model and cross-talk relationship exists between PPAR-γ and α1-adrenoceptors, ANG II in systemic vasculature of SHRs.

Item Type: Article
Uncontrolled Keywords: Diabetes; Spontaneously hypertensive rats; Pioglitazone; PPAR-γ; Angiotensin II; Adiponectin
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 08 Oct 2019 01:45
Last Modified: 08 Oct 2019 01:45
URI: http://eprints.um.edu.my/id/eprint/22693

Actions (login required)

View Item View Item