Enhanced amperometric detection of paracetamol by immobilized cobalt ion on functionalized MWCNTs - Chitosan thin film

Akhter, Shamima and Basirun, Wan Jefrey and Alias, Yatimah and Johan, Mohd Rafie and Bagheri, Samira and Shalauddin, Md and Ladan, Magaji and Anuar, Nadzirah Sofia (2018) Enhanced amperometric detection of paracetamol by immobilized cobalt ion on functionalized MWCNTs - Chitosan thin film. Analytical Biochemistry, 551. pp. 29-36. ISSN 0003-2697

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Official URL: https://doi.org/10.1016/j.ab.2018.05.004

Abstract

In the present study, a nanocomposite of f-MWCNTs-chitosan-Co was prepared by the immobilization of Co(II) on f-MWCNTs-chitosan by a self-assembly method and used for the quantitative determination of paracetamol (PR). The composite was characterized by field emission scanning electron microscopy (FESEM) and energy dispersive x-ray analysis (EDX). The electroactivity of cobalt immobilized on f-MWCNTs-chitosan was assessed during the electro-oxidation of paracetamol. The prepared GCE modified f-MWCNTs/CTS-Co showed strong electrocatalytic activity towards the oxidation of PR. The electrochemical performances were investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). Under favorable experimental conditions, differential pulse voltammetry showed a linear dynamic range between 0.1 and 400 μmol L−1 with a detection limit of 0.01 μmol L−1 for the PR solution. The fabricated sensor exhibited significant selectivity towards PR detection. The fabricated sensor was successfully applied for the determination of PR in commercial tablets and human serum sample.

Item Type: Article
Uncontrolled Keywords: Paracetamol; Electrochemical sensor; f-Multi-wall carbon nanotube; Chitosan; Cobalt
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Divisions: Faculty of Science > Dept of Chemistry
Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Sep 2019 02:31
Last Modified: 27 Sep 2019 02:31
URI: http://eprints.um.edu.my/id/eprint/22606

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