Akhter, Shamima and Basirun, Wan Jefrey and Alias, Yatimah and Johan, Mohd Rafie and Bagheri, Samira and Shalauddin, Md and Ladan, Magaji and Anuar, Nadzirah Sofia (2018) Enhanced amperometric detection of paracetamol by immobilized cobalt ion on functionalized MWCNTs - Chitosan thin film. Analytical Biochemistry, 551. pp. 29-36. ISSN 0003-2697, DOI https://doi.org/10.1016/j.ab.2018.05.004.
Full text not available from this repository.Abstract
In the present study, a nanocomposite of f-MWCNTs-chitosan-Co was prepared by the immobilization of Co(II) on f-MWCNTs-chitosan by a self-assembly method and used for the quantitative determination of paracetamol (PR). The composite was characterized by field emission scanning electron microscopy (FESEM) and energy dispersive x-ray analysis (EDX). The electroactivity of cobalt immobilized on f-MWCNTs-chitosan was assessed during the electro-oxidation of paracetamol. The prepared GCE modified f-MWCNTs/CTS-Co showed strong electrocatalytic activity towards the oxidation of PR. The electrochemical performances were investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). Under favorable experimental conditions, differential pulse voltammetry showed a linear dynamic range between 0.1 and 400 μmol L−1 with a detection limit of 0.01 μmol L−1 for the PR solution. The fabricated sensor exhibited significant selectivity towards PR detection. The fabricated sensor was successfully applied for the determination of PR in commercial tablets and human serum sample.
| Item Type: | Article |
|---|---|
| Funders: | University Malaya, Ministry of Higher Education (MOHE) and University of Malaya Centre for Ionic Liquids (UMCiL) through grant numbers of FP039 2016A and RH 2017 |
| Uncontrolled Keywords: | Paracetamol; Electrochemical sensor; f-Multi-wall carbon nanotube; Chitosan; Cobalt |
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Divisions: | Faculty of Science > Department of Chemistry Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 27 Sep 2019 02:31 |
| Last Modified: | 27 Sep 2019 02:31 |
| URI: | http://eprints.um.edu.my/id/eprint/22606 |
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