Alkaloids from Alphonsea elliptica barks and their biological activities

Aldulaimi, Ahmed Kareem Obaid and Abdul Azziz, Saripah Salbiah Syed and Bakri, Yuhanis Mhd and Nafiah, Mohd Azlan and Awang, Khalijah and Aowda, Saadon Abdulla and Litaudon, Marc and Hassan, Norazian Mohd and Naz, Humera and Abbas, Phirdaous and Hashim, Yumi Zuhanis Has-Yun and Majhool, Alhussein Arkan (2018) Alkaloids from Alphonsea elliptica barks and their biological activities. Journal of Global Pharma Technology, 10 (8). pp. 270-275. ISSN 0975-8542

Full text not available from this repository.
Official URL: http://www.jgpt.co.in/index.php/jgpt/article/view/...

Abstract

This study was carried out to investigate the phytochemicals from the barks of Alphonsea elliptica. The barks were harvested from Hutan Simpan Sembarong, Kluang, Johor; and extracted using dichloromethane (DCM), hexane and methanol successively. Isolation of dichloromethane crude extract was then performed using silica gel column chromatography and preparative thin layer chromatography (PTLC)techniques. Structural identification were carried out via 1D and 2D NMR, UV, IR, MS and comparison with reported data. Phytochemical study of the barks led tothe isolation of five alkaloid in which two were oxoaporphines; atherospermidine (1) and liriodenine (2),two were dioxoaporphines;cepharadione A (3) and N- methylouregidione (4), and an azafluorenone alkaloid;kinabaline (5). The hexane, DCM, and methanol crude extracts, together with five isolated alkaloids, were tested for theirradical scavenging activity,inhibition of xanthine oxidase activities and cytotoxicity. Atherospermidine and liriodenine possessed antioxidative activities with IC50 value of 20.17 and 10.73, respectively. Atherospermidine, liriodenine, N-methylouregidione and kinabaline showed xanthine oxidase inhibitiory activityof 46.29, 7.66, 42.10 and 50.72 μM,respectively. Meanwhile, atherospermidine, liriodenine, cepharadione A and kinabaline showed cytotoxicity against breast cancer cell line with IC50 89, 86, 79.85 and 62 µg/mL respectively. All the alkaloids tested in this study were isolated for the first time from this species while Cepharadione A is reported for the first time in a species belongs to Alphonsea genus.

Item Type: Article
Uncontrolled Keywords: Alkaloids; Alphonsea ellipticaHk. f. et Th; Cytotoxicity; Radical scavenging activity; Xanthine oxidase
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 26 Sep 2019 03:30
Last Modified: 26 Sep 2019 03:30
URI: http://eprints.um.edu.my/id/eprint/22575

Actions (login required)

View Item View Item