Ali, Ahmed Khalaf and Abubakar, Adamu Abdul and Kaka, Ubedullah and Radzi, Zamri and Khairuddin, Nurul Hayah and Yusoff, Md Sabri Mohd and Loqman, Mohamad Yusof (2018) Histological changes of immediate skin expansion of the distal limb of rats. Veterinary World, 11 (12). pp. 1706-1711. ISSN 0972-8988, DOI https://doi.org/10.14202/vetworld.2018.1706-1711.
Full text not available from this repository.Abstract
Aim: Tissue expansion is an applicable technique to reconstruct many surgical defects. The aim of this research was to evaluate the histological changes caused by immediate skin tissue expansion in rats as an animal model. Materials and Methods: Immediate skin tissue expansion in 18 adult female rats was performed using three different sizes (small, medium, and big) of polymethylmethacrylate tissue expanders at the dorsal surface of the metatarsal area of the right limb. The contralateral limb was served as the control. The tissue expanders were surgically implanted and kept for 15 days. Results: The immediate skin expansion resulted in histological changes such as the increased thickness of the epidermal layer, the reduction of the dermal layer, an elevated number of fibroblast as well as increased vascularity. Furthermore, skin adnexal structures such as hair follicles and sebaceous glands were farther apart. Conclusion: The rat skin was able to rapidly adjust and compensate against a specific range of immediate mechanical expansion. The histological changes suggest that the tissues were prepared to withstand the increased external forces, in addition to create possibly additional skin in a relatively short-term period.
| Item Type: | Article |
|---|---|
| Funders: | Research Grant Scheme (FRGS) from the Ministry of Higher Education Malaysia FRGS/1/2012/ SGO5/UPM/02/9, High Impact Research MoE Grant UM.C/625/1/HIR/MOHE/DENT/21 from the Ministry of Education Malaysia |
| Uncontrolled Keywords: | histology; rats; skin expansion; tissue expander |
| Subjects: | R Medicine |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Sep 2019 01:45 |
| Last Modified: | 26 Sep 2019 01:45 |
| URI: | http://eprints.um.edu.my/id/eprint/22566 |
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