Fabrication of platinum nitrogen-doped graphene nanocomposite modified electrode for the electrochemical detection of acetaminophen

Anuar, Nadzirah Sofia and Basirun, Wan Jefrey and Ladan, Magaji and Shalauddin, Md and Mehmood, Muhammad Shahid (2018) Fabrication of platinum nitrogen-doped graphene nanocomposite modified electrode for the electrochemical detection of acetaminophen. Sensors and Actuators B: Chemical, 266. pp. 375-383. ISSN 0925-4005

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Official URL: https://doi.org/10.1016/j.snb.2018.03.138

Abstract

An electrochemical sensor for the determination of acetaminophen (AC) was fabricated on glassy carbon electrode (GCE) modified with platinum nitrogen-doped graphene (Pt/NGr) nanocomposite. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square-wave voltammetry (SWV) were performed to investigate the electrochemical behaviour of AC. From the electrochemical results, the synergy between platinum nanoparticles and nitrogen-doped graphene improved the interfacial electron transfer process, thus exhibited a higher catalytic performance towards the electrochemical oxidation of AC. A linear range between 0.05–90 μmol L−1 for the determination of AC was achieved with a limit of detection of 0.008 μmol L−1. The prepared sensor demonstrated acceptable reproducibility, stability and good selectivity in the presence of interferences such as ascorbic acid, p-aminophenol and dopamine. In addition, this method showed satisfactory results in commercial tablets.

Item Type: Article
Uncontrolled Keywords: Acetaminophen; Electrochemical sensor; Graphene; Platinum nanoparticles
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Faculty of Science > Dept of Physics
Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 20 Sep 2019 02:49
Last Modified: 20 Sep 2019 02:49
URI: http://eprints.um.edu.my/id/eprint/22464

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