Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy

Chambre, Laura and Saw, Wen Shang and Ekineker, Gülçin and Kiew, Lik Voon and Chong, Wu Yi and Lee, Hong Boon and Chung, Lip Yong and Bretonnière, Yann and Dumoulin, Fabienne and Sanyal, Amitav (2018) Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy. Bioconjugate Chemistry, 29 (12). pp. 4149-4159. ISSN 1043-1802

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Official URL: https://doi.org/10.1021/acs.bioconjchem.8b00787

Abstract

Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photoinduced killing efficiency was tested against three cell lines: human breast adenocarcinoma (MDA-MB-231 and MCF7) and pancreatic adenocarcinoma (AsPC-1) cells, and a predominant photodynamic mechanism at 450 nm and a mixed photodynamic and photothermal effect at 635 nm was observed. This innovative access to photosensitizing nanogels is a proof of concept, and opens new perspectives toward the preparation of optimized nanophotosensitizers.

Item Type: Article
Uncontrolled Keywords: Cell Line, Tumor; Cross-Linking Reagents; Gels; Humans; Hyperthermia, Induced; Nanostructures; Photochemotherapy; Porphyrins; Surface-Active Agents
Subjects: Q Science > QD Chemistry
R Medicine
T Technology > TP Chemical technology
Divisions: Faculty of Medicine
Deputy Vice Chancellor (Research & Innovation) Office > Photonics Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 11 Sep 2019 03:22
Last Modified: 11 Sep 2019 03:22
URI: http://eprints.um.edu.my/id/eprint/22286

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