Hepatitis B virus infection among children of hepatitis B surface antigen positive mothers in a Malaysian hospital

Chan, Wah Kheong and Yeoh, Kee Ying and Lim, Chia Ying and Lai, Su Meng and Lee, Jac Lyn and Leow, Alex Hwong Ruey and Goh, Khean Lee (2018) Hepatitis B virus infection among children of hepatitis B surface antigen positive mothers in a Malaysian hospital. Medical Journal of Malaysia, 73 (3). pp. 137-140. ISSN 0300-5283

Full text not available from this repository.
Official URL: http://www.e-mjm.org/2018/v73n3/hepatitis-B-virus-...

Abstract

Introduction: There have been no published data on the transmission of hepatitis B virus (HBV) infection among children of hepatitis B surface antigen (HBsAg) positive mothers in Malaysia. Methods: This is a cross-sectional study of all the children of HBsAg-positive mothers who delivered at the University of Malaya Medical Centre between 1993 and 2000. Results: A total of 60 HBsAg-positive mothers and their 154 children participated in the study. HBsAg was detected in four children (2.6%) while IgG antibody to the hepatitis B core antigen (anti-HBc IgG) was detected in seventeen children (11.0%). The mother’s age at childbirth was significantly lower in the children with detectable HBsAg (22.5±6.1 years vs. 29.7±4.5 years, p=0.043) and anti-HBc IgG (26.6±6.1 years vs. 30.0±4.3 years, p=0.004). Children born in the 1980s were significantly more likely to have detectable HBsAg (18.8% vs. 0.7%, p=0.004) and anti-HBc IgG (37.5% vs. 8.0%, p=0.000) compared with those born later. All children with detectable HBsAg were born via spontaneous vaginal delivery, and hepatitis B immunoglobulin was either not given or the administration status was unknown. The majority of mothers with chronic HBV infection (70.4%) were not under any regular follow-up for their chronic HBV infection and the main reason was the lack of awareness of the need to do so (47.4%). Conclusion: Transmission of HBV infection among children of HBsAg-positive mothers in Malaysia is low. However, attention needs to be given to the high rate of HBsAg-positive mothers who are not on any regular follow-up.

Item Type: Article
Uncontrolled Keywords: HBV; Malaysia; Vertical transmission
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 06 Sep 2019 06:23
Last Modified: 06 Sep 2019 06:23
URI: http://eprints.um.edu.my/id/eprint/22275

Actions (login required)

View Item View Item