Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell

Fish-Low, Cheng Yee and AbuBakar, Sazaly and Othman, Fauziah and Chee, Hui Yee (2018) Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell. Tropical Biomedicine, 35 (4). pp. 1154-1159. ISSN 0127-5720

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Official URL: http://msptm.org/files/Vol35No4/1154-1159-Chee-HY....

Abstract

Dengue virus (DENV) is maintained and circulated in both sylvatic/enzootic and endemic/human cycles and spill over infection of sylvatic DENV into human populations has been reported. Extensive deforestation and increase human activities in forest may increase the risk of human exposure to sylvatic dengue infection and this may become a threat to human. Present study investigated the changes in cell morphology and viral morphogenesis upon infection with sylvatic and endemic ecotypes in human monocytic U-937 cells using transmission electron microscopy. Autophagy, a process that is either pro-viral or anti-viral, was observed in U-937 cells of both infections, however only the replication of endemic DENV was evidenced. An insight into the infection responses of sylvatic progenitors of DENV in susceptible host cells may provide better understanding on dengue emergence in human populations.

Item Type: Article
Uncontrolled Keywords: Dengue; Dengue Virus; DENV serotypes
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 26 Aug 2019 06:31
Last Modified: 26 Aug 2019 06:31
URI: http://eprints.um.edu.my/id/eprint/22073

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