One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives

Hamid, Sharifah Bee Abd and Titinchi, Salam J.J. and Abbo, Hanna and Khaligh, Nader Ghaffari (2018) One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives. Polycyclic Aromatic Compounds, 38 (2). pp. 189-198. ISSN 1040-6638

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Official URL: https://doi.org/10.1080/10406638.2016.1194298

Abstract

An environmentally benign, simple, and efficient procedure has been developed for the one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives by the reaction of the variety of aryl-aldehydes, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and urea in the presence of catalytic amount of poly(N-vinylpyridinium) hydrogen sulfate in glycerol. The present method affords non-toxic and non-corrosive medium, short reaction times, high yield of the products, mild reaction conditions as well as simple experimental and isolation procedures. The catalyst can be recycled by simple filtration and reused without any significant reduction in its activity.

Item Type: Article
Uncontrolled Keywords: Green chemistry; one-pot multicomponent reaction; poly(N-vinylpyrimidinum) hydrogen sulfate; pyrazolo[3,4-d]pyrimidine-6-one
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 20 Aug 2019 03:30
Last Modified: 20 Aug 2019 03:30
URI: http://eprints.um.edu.my/id/eprint/21965

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