Huri, Hasniza Zaman and Chua, Chew Huey and Mustafa, Norasyikin and Mohamad, Nor Fadhilah and Kamalden, Tengku Ain (2018) Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia. Brazilian Journal of Pharmaceutical Sciences, 54 (2). e17484. ISSN 2175-9790, DOI https://doi.org/10.1590/s2175-97902018000217484.
Full text not available from this repository.Abstract
The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Type 2 Diabetes Mellitus; Anti-diabetic agents; Microvascular complication; Diabetic macula edema; Diabetic retinopathy; Malaysia |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Aug 2019 04:18 |
| Last Modified: | 07 Aug 2019 04:18 |
| URI: | http://eprints.um.edu.my/id/eprint/21853 |
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