Khor, Chee Sieng and Mohd Rahim, Nurul Farhana and Hassan, Habibi and Chandren, Josephine Rebecca and Nore, Siti Sarah and Johari, Jefree and Loong, Shih Keng and Abd Jamil, Juraina and Khoo, Jing Jing and Lee, Hai Yen and Pike, Brian L. and Wong, Li Ping and Lim, Yvonne Ai Lian and Zandi, Keivan and AbuBakar, Sazaly (2018) Seroprevalence of Q Fever Among the Indigenous People (Orang Asli) of Peninsular Malaysia. Vector-Borne and Zoonotic Diseases, 18 (3). pp. 131-137. ISSN 1530-3667, DOI https://doi.org/10.1089/vbz.2017.2153.
Full text not available from this repository.Abstract
Q fever is a disease caused by Coxiella burnetii. It is a disease of public health concern in many parts of the world. In this study, we described the seroprevalence of Q fever among selected populations of Orang Asli (OA), indigenous people, many of whom live within the forest fringe areas of Peninsular Malaysia. Serum samples were obtained from 887 OA participants from selected villages. Samples were analyzed for the presence of IgG antibodies reactive against C. burnetii by enzyme-linked immunosorbent assay. Statistical methods were used to identify possible associations between seropositivity for C. burnetii and a number of demographic variables obtained from the questionnaires. In total, 9.6% (n = 85/887) of the serum samples were reactive to C. burnetii. Statistical results suggest that elderly male OA residing in OA village, Bukit Payung, were most likely to be tested seropositive for C. burnetii. This study suggests that OA are at a significant risk of contracting C. burnetii infection, and both demographic and geographic factors are important contributors to this risk. Further prospective studies are needed to establish the true burden of C. burnetii infection within the indigenous population as well as within Peninsular Malaysia as a whole.
| Item Type: | Article |
|---|---|
| Funders: | U.S. Naval Medical Research Center—Asia (Work Unit no. D-1101) and the U.S. Department of State, Biosecurity Engagement Program (NAMRU: J-55025-75053), University of Malaya Research Grant (UMRG: FL001-13HTM), University Research Grant 2015, Center of Excellence (COE) Programs (RU016-2015), Ministry of Higher Education (MOHE), High Impact Research (HIR)-MOHE Grant (E000013-20001) |
| Uncontrolled Keywords: | Coxiella burnetii; infectious diseases; Malaysia; Orang Asli; Q fever; seroprevalence |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Jul 2019 04:13 |
| Last Modified: | 15 Jul 2019 04:13 |
| URI: | http://eprints.um.edu.my/id/eprint/21607 |
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