Lim, Li Min and Woo, Yen Yen and De Bruyne, Jessie Anne and Nathan, Anna Marie and Kee, Sze Ying and Chan, Yoke Fun and Chiam, Chun Wei and Eg, Kah Peng and Thavagnanam, Surendran and Sam, I-Ching (2018) Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia. PLoS ONE, 13 (10). e0205795. ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0205795.
Full text not available from this repository.Abstract
Objectives To describe the severity, human adenovirus (HAdV) type and respiratory morbidity following adenovirus pneumonia in children. Methodology Retrospective review of children under 12 years of age, admitted with HAdV pneumonia, between January 2011 and July 2013, in a single centre in Malaysia. HAdV isolated from nasopharyngeal secretions were typed by sequencing hypervariable regions 1–6 of the hexon gene. Patients were reviewed for respiratory complications. Results HAdV was detected in 131 children of whom 92 fulfilled inclusion criteria. Median (range) age was 1.1 (0.1–8.0) years with 80% under 2 years. Twenty percent had severe disease with a case-fatality rate of 5.4%. Duration of admission (p = 0.02) was independently associated with severe illness. Twenty-two percent developed respiratory complications, the commonest being bronchiolitis obliterans (15.2%) and recurrent wheeze (5.4%). The predominant type shifted from HAdV1 and HAdV3 in 2011 to HAdV7 in 2013. The commonest types identified were types 7 (54.4%), 1(17.7%) and 3 (12.6%). Four out of the five patients who died were positive for HAdV7. Infection with type 7 (OR 8.90, 95% CI 1.32, 59.89), family history of asthma (OR 14.80, 95% CI 2.12–103.21) and need for invasive or non-invasive ventilation (OR 151.84, 95% CI 9.93–2.32E) were independent predictors of respiratory complications. Conclusions One in five children admitted with HAdV pneumonia had severe disease and 22% developed respiratory complications. Type 7 was commonly isolated in children with severe disease. Family history of asthma need for invasive or non-invasive ventilation and HAdV 7 were independent predictors of respiratory complications.
| Item Type: | Article |
|---|---|
| Funders: | University Malaya (Research Grant UM.TNC2/RC/HTM/RP026-14HTM, Postgraduate Research Grant PO027-2015A, High Impact Research Grant UM.C/625/1/HIR/MOHE/MED/42 |
| Uncontrolled Keywords: | Adenoviridae; Adenoviridae Infections; Bronchiolitis Obliterans; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Malaysia; Male; Phylogeny; Pneumonia, Viral; Respiratory Sounds; Retrospective Studies |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 31 May 2019 03:41 |
| Last Modified: | 31 May 2019 03:41 |
| URI: | http://eprints.um.edu.my/id/eprint/21441 |
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