Mat, Sumaiyah and Jaafar, Mohamad Hasif and Sockalingam, Sargunan and Raja, Jasmin and Kamaruzzaman, Shahrul Bahyah and Chin, Ai-Vyrn and Abbas, Azlina Amir and Chan, Chee Ken and Hairi, Noran Naqiah and Othman, Sajaratulnisah and Cumming, Robert and Tan, Maw Pin (2018) Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR). International Journal of Rheumatic Diseases, 21 (5). pp. 930-936. ISSN 1756-1841, DOI https://doi.org/10.1111/1756-185X.13279.
Full text not available from this repository.Abstract
Aim: To determine the association between vitamin D and knee pain among participants of the Malaysian Elders Longitudinal Research (MELoR) study. Method: This was a cross-sectional study from the MELoR study consisting of a representative group of 1011 community-dwelling older persons (57% female), mean age 86.5 (54–94) years; 313 were Malays, 367 Chinese and 330 Indians. Participants were asked if they had knee pain. Levels of serum 25-hydroxy cholecalciferol (25-[OH]D), an indicator of vitamin D status, were measured using routine laboratory techniques. Results: In unadjusted analysis, presence of knee pain was significantly associated with vitamin D deficiency (odds ratio [OR] 1.42; 95% confidence interval (CI) 1.08–1.85, P 0.011). Vitamin D levels were significantly associated with ethnicity differences where Malays (OR 7.08; 95% CI 4.94–10.15) and Indians (OR 6.10; 95% CI 4.28–9.71) have lower levels of vitamin D compared to Chinese. Subsequent multivariate analysis revealed that the association between vitamin D deficiency and knee pain was confounded by ethnic differences. Conclusion: A previous study suggested that vitamin D deficiency was associated with knee pain. This relationship was reproduced in our study, but we further established that the association was explained by ethnic variations. As vitamin D status is dependent on skin tone, diet and sunlight exposure, which are all effected by ethnicity, future studies are now required to determine whether a true relationship exists between vitamin D and knee pain.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | aged; Asia; ethnic differences; knee pain; osteoarthritis; vitamin D deficiency |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 27 May 2019 04:04 |
| Last Modified: | 27 May 2019 04:04 |
| URI: | http://eprints.um.edu.my/id/eprint/21317 |
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