Mohammed, Issam Ahmed and Ahmed, Mahmood and Ikram, Rabia and Qadir, Muhammad Abdul and Hussain, Riaz (2018) 1,3-oxazepine compounds derived from azomethine: Synthesis, characterization and antibacterial evaluation. Latin American Journal of Pharmacy, 37 (3). pp. 540-546. ISSN 0326-2383,
Full text not available from this repository.Abstract
Two azomethines, namely 2-methoxy-4-phenyliminomethyl-phenol (1) and 4-[(2,4-dinitro-phenyl)-hydrazonomethyl]-2-methoxy-phenol (2) were prepared between the reaction of vanillin with aniline and 2,4-dinitrophenylhydrazine, respectively. Subsequently, these two azomethines were reacted via direct cyclic addition with maleic anhydride, phthalic anhydride and succinic anhydride, respectively, yielded a series of new 1,3-oxazepines (3-8). All the synthesized compounds were characterized on the basis of FT-IR, NMR, MS and elemental analysis (CHN). Disk diffusion and 96-well plate assay methods were employed for zone of inhibition and minimum inhibitory concentration determination respectively to investigate the antibacterial activities. Our studies showed that compound 5 showed promising antibacterial activities with zone of inhibition 24.7 mm against S. aureus, AI value 77.2 % compare to standard ciprofloxacin and MIC was 31.25 μg/mL.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antibacterial activities; Azomethines; MIC |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 May 2019 08:52 |
| Last Modified: | 15 May 2019 08:52 |
| URI: | http://eprints.um.edu.my/id/eprint/21247 |
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