Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)

Moy, Foong Ming and Greenwood, Darren Charles and Cade, Janet Elizabeth (2018) Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS). BMJ Open, 8 (9). e022599. ISSN 2044-6055

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Official URL: https://doi.org/10.1136/bmjopen-2018-022599

Abstract

OBJECTIVES: Breast cancer is associated with overweight and obesity after menopause. However, clothing size as a proxy of adiposity in predicting postmenopausal breast cancer is not widely studied. We aimed to explore the relationships between postmenopausal breast cancer risk with adipose indicators (including clothing sizes) and weight change over adulthood. DESIGN: Prospective cohort study. SETTING: England, Wales and Scotland. PARTICIPANTS: 17 781 postmenopausal women from the UK Women's Cohort Study. PRIMARY OUTCOME MEASURE: Incident cases of malignant breast cancers (International Classification of Diseases (ICD) 9 code 174 and ICD 10 code C50). RESULTS: From 282 277 person-years follow-up, there were 946 incident breast cancer cases with an incidence rate of 3.35 per 1000 women. Body mass index (HR: 1.04; 95% CI: 1.02 to 1.07), blouse size (HR: 1.10; 1.03 to 1.18), waist circumference (HR: 1.07; 1.01 to 1.14) and skirt size (HR: 1.14;1.06 to 1.22) had positive associations with postmenopausal breast cancer after adjustment for potential confounders. Increased weight over adulthood (HR: 1.02; 1.01 to 1.03) was also associated with increased risk for postmenopausal breast cancer. CONCLUSIONS: Blouse and skirt sizes can be used as adipose indicators in predicting postmenopausal breast cancer. Maintaining healthy body weight over adulthood is an effective measure in the prevention of postmenopausal breast cancer.

Item Type: Article
Uncontrolled Keywords: blouse size; post-menopausal breast cancer; skirt size; Uk women cohort; weight change
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 09 May 2019 08:39
Last Modified: 09 May 2019 08:39
URI: http://eprints.um.edu.my/id/eprint/21213

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