An inhibitory action of chitosan nanoparticles against pathogenic bacteria and fungi and their potential applications as biocompatible antioxidants

MubarakAli, Davoodbasha and LewisOscar, Felix and Gopinath, Venkatraman and Alharbi, Naiyf Sultan and Alharbi, Sulaiman Ali and Thajuddin, Nooruddin (2018) An inhibitory action of chitosan nanoparticles against pathogenic bacteria and fungi and their potential applications as biocompatible antioxidants. Microbial Pathogenesis, 114. pp. 323-327. ISSN 0882-4010

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Official URL: https://doi.org/10.1016/j.micpath.2017.11.043

Abstract

Chitosan is the second most abundant polymer obtained from the byproduct of seafood. Chitosan and its derivatives and chitosan loaded drugs are the recent area of interest against microbial pathogenesis. The cationic chitosan nanoparticles (ChNPs) interact with the anionic surfaces of the microbial cell membrane, which promotes antimicrobial activity. Although, ChNPs are potential against pathogenic microbes, selection of adaptable, suitable and cost effective synthesis method is much important. In the present study, ChNPs were synthesized adopting ionic gelation using sodium tripolyphosphate as a cross linking agent and characterized by FTIR, DLS, SEM and TEM analysis. ChNPs were investigated for antimicrobial activity against bacterial (Escherichia coli and Staphylococcus aureus) and fungal (Candida albicans) pathogens. ChNPs showed bactericidal activity at the lower minimum inhibitory concentration of about 40–80 μg mL−1. Interestingly, ChNPs exhibits biocompatible antioxidant property by inhibiting DPPH free radicals at 76% and also proven to be a potential candidate against the microbial pathogenesis with an inevitable applications in biomedicine.

Item Type: Article
Uncontrolled Keywords: Chitosan nanoparticles; Colloids; Ionic gelation; Zeta potential; Antimicrobial
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 09 May 2019 08:36
Last Modified: 09 May 2019 08:36
URI: http://eprints.um.edu.my/id/eprint/21212

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