A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk

Muhammad, Aliyu and Hajian, Reza and Yusof, Nor Azah and Shams, Nafiseh and Abdullah, Jaafar and Woi, Pei Meng and Garmestani, Hamid (2018) A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk. RSC Advances, 8 (5). pp. 2714-2722. ISSN 2046-2069

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Official URL: https://doi.org/10.1039/c7ra07544h

Abstract

Antibiotic residues in milk are of great concern for health regulatory agencies, milk consumers, and dairy farmers due to their destructive effects, ranging from allergic reactions, antibiotic resistance and the ability to interfere with the production of fermented products (i.e. cheese and yogurt). Therefore, a reliable, fast, and simple method needs to be developed to monitor antibiotic residues in milk samples before distribution to consumers. In this study, the first sensitive electrochemical sensor is presented for the determination of thiamphenicol (TAP), a broad-spectrum antibiotic in bovine milk. In the fabrication process, a screen printed electrode (SPE) was modified with gold nanoparticles (AuNPs) and carbon nanotubes (CNTs) using ethylenediamine (en) as a cross linker. Cyclic voltammetry studies showed an adsorptive control process for the electro-oxidation of TAP at-0.1 V on the modified electrode of SPE/CNT/en/AuNPs. Differential pulse voltammetry (DPV) was applied for the quantitative determination of TAP under optimized conditions (0.1 M citrate buffer, pH 6.0, accumulation potential-0.7 V, and accumulation time 150 s). A DPV study for TAP shows a wide linear calibration range of 0.1-30 μM with the detection limit of 0.003 μM. Furthermore, the developed sensor displays high sensitivity, reproducibility, repeatability, and good stability for the detection of TAP. The proposed sensor was successfully applied for the determination of spiked TAP in bovine milk with satisfactory results.

Item Type: Article
Uncontrolled Keywords: Antibiotic resistance; Broad spectrum antibiotics; Differential pulse voltammetry; Ethylenediamine (en); Optimized conditions; Quantitative determinations; Screen printed electrodes; Screen-printed carbon electrodes
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 09 May 2019 08:04
Last Modified: 09 May 2019 08:04
URI: http://eprints.um.edu.my/id/eprint/21207

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