Utility of Using the Montreal Cognitive Assessment (MoCA) as a Screening Tool for HIV-Associated Neurocognitive Disorders (HAND) In Multi-Ethnic Malaysia

Mukherjee, Trena and Sakthivel, Rishanantini and Ho, Yen Fong and McStea, Megan and Chong, Meng Li and Omar, Sharifah Faridah Syed and Chin, Ai-Vyrn and Kamaruzzaman, Shahrul Bahyah and Kamarulzaman, Adeeba and Rajasuriar, Reena and Cysique, Lucette A. (2018) Utility of Using the Montreal Cognitive Assessment (MoCA) as a Screening Tool for HIV-Associated Neurocognitive Disorders (HAND) In Multi-Ethnic Malaysia. AIDS and Behavior, 22 (10). pp. 3226-3233. ISSN 1090-7165

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Official URL: https://doi.org/10.1007/s10461-018-2073-x

Abstract

This study determines the optimal cut-off scores for the Montreal Cognitive Assessment (MoCA) to detect HIV-associated neurocognitive disorders (HAND) in a multi-ethnic Malaysian HIV-positive cohort by developing demographically corrected normative standards among 283 HIV-negative community-based controls with overlapping demographic characteristics. The norms (corrected for age, sex, education, ethnicity) were applied to 342 HIV-positive virally suppressed individuals on cART. Impairment rates were classified using the Global Deficit Score (GDS ≥.5) method. The MoCA was also scored according to the recommended cut-off of ≤ 26, and functional decline was applied to both impairment definitions to classify HAND per the Frascati criteria. The ≤ 26 cut-off considerably overestimated cognitive impairment in both samples (59.4% HIV-negative; 69.3% HIV-positive). In contrast, corrected scores yielded impairment rates consistent with what has been reported internationally in virally suppressed cohorts (23.4% with 83.3% mild impairment, 16.7% moderate impairment). A supplemental file allowing the computation of corrected MoCA scores and impairment status is included.

Item Type: Article
Uncontrolled Keywords: Hand; HIV; Malaysia; MoCA; Normative values
Subjects: R Medicine
Divisions: Faculty of Medicine
Centre of Excellence for Research in AIDS (CERiA)
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 09 May 2019 06:59
Last Modified: 09 May 2019 06:59
URI: http://eprints.um.edu.my/id/eprint/21195

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