Mukherjee, Trena and Sakthivel, Rishanantini and Ho, Yen Fong and McStea, Megan and Chong, Meng Li and Omar, Sharifah Faridah Syed and Chin, Ai-Vyrn and Kamaruzzaman, Shahrul Bahyah and Kamarulzaman, Adeeba and Rajasuriar, Reena and Cysique, Lucette A. (2018) Utility of Using the Montreal Cognitive Assessment (MoCA) as a Screening Tool for HIV-Associated Neurocognitive Disorders (HAND) In Multi-Ethnic Malaysia. AIDS and Behavior, 22 (10). pp. 3226-3233. ISSN 1090-7165, DOI https://doi.org/10.1007/s10461-018-2073-x.
Full text not available from this repository.Abstract
This study determines the optimal cut-off scores for the Montreal Cognitive Assessment (MoCA) to detect HIV-associated neurocognitive disorders (HAND) in a multi-ethnic Malaysian HIV-positive cohort by developing demographically corrected normative standards among 283 HIV-negative community-based controls with overlapping demographic characteristics. The norms (corrected for age, sex, education, ethnicity) were applied to 342 HIV-positive virally suppressed individuals on cART. Impairment rates were classified using the Global Deficit Score (GDS ≥.5) method. The MoCA was also scored according to the recommended cut-off of ≤ 26, and functional decline was applied to both impairment definitions to classify HAND per the Frascati criteria. The ≤ 26 cut-off considerably overestimated cognitive impairment in both samples (59.4% HIV-negative; 69.3% HIV-positive). In contrast, corrected scores yielded impairment rates consistent with what has been reported internationally in virally suppressed cohorts (23.4% with 83.3% mild impairment, 16.7% moderate impairment). A supplemental file allowing the computation of corrected MoCA scores and impairment status is included.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya High Impact Research grants HIR/MOHE H-20001-E000001, UM.0000099/HIR.C3, National Institute of Allergy & Infectious Diseases of the National Institutes of Health under award number T32AI114398 |
| Uncontrolled Keywords: | Hand; HIV; Malaysia; MoCA; Normative values |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine Centre of Excellence for Research in AIDS (CERiA) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 May 2019 06:59 |
| Last Modified: | 09 May 2019 06:59 |
| URI: | http://eprints.um.edu.my/id/eprint/21195 |
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