Yehye, Wageeh Abdulhadi and Nath, Amit Ranjan (2018) Acid Hydrazide: A Potential Reagent for the Synthesis of Semicarbazones. Synthesis, 50 (21). pp. 4301-4312. ISSN 0039-7881, DOI https://doi.org/10.1055/s-0037-1609557.
Full text not available from this repository.Abstract
Complex semicarbazone derivatives were successfully synthesized from substituted semicarbazides in acidic ethanol upon heating in the presence of aldehyde. The reaction is functional group tolerant and chemoselective because no terminal hydrazine moiety is present in the substituted semicarbazides. Thus, functional groups such as esters and acetyls, which are prone to reaction with hydrazine, can also be used in this reaction because the terminal hydrazine moiety of the acid hydrazide was protected by aryl isocyanates in order to prepare substituted semicarbazides. In addition, neither of the aryl groups of semicarbazone are dependent on the starting materials (acid hydrazide) and can be changed upon demand. Thus, this reaction protocol provides a simple and effective alternative for the preparation of a wide variety of semicarbazones that could not be synthesized by utilizing conventional methods.
| Item Type: | Article |
|---|---|
| Funders: | Grand Challenge (GC001C-14AET), PPP Grant PG208-2015B provided by the University of Malaya and Ministry of Higher Education, Malaysia (MOHE) |
| Uncontrolled Keywords: | acid hydrazide; hydrazine; nucleophilic substitution reaction; semicarbazones; substituted semicarbazides |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 May 2019 05:59 |
| Last Modified: | 08 May 2019 05:59 |
| URI: | http://eprints.um.edu.my/id/eprint/21162 |
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