Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii

Nugroho, Alfarius Eko and Zhang, Wenjia and Hirasawa, Yusuke and Tang, Yiming and Wong, Chin Piow and Kaneda, Toshio and Hadi, A. Hamid A. and Morita, Hiroshi (2018) Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii. Journal of Natural Products, 81 (11). pp. 2600-2604. ISSN 0163-3864

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Official URL: https://doi.org/10.1021/acs.jnatprod.8b00749

Abstract

Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.

Item Type: Article
Uncontrolled Keywords: alkaloid; antineoplastic agent; bisleuconothine B; bisleuconothine C; bisleuconothine D; unclassified drug
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 Apr 2019 01:36
Last Modified: 30 Apr 2019 01:36
URI: http://eprints.um.edu.my/id/eprint/21094

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