Nugroho, Alfarius Eko and Zhang, Wenjia and Hirasawa, Yusuke and Tang, Yiming and Wong, Chin Piow and Kaneda, Toshio and A. Hadi, A. Hamid and Morita, Hiroshi (2018) Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii. Journal of Natural Products, 81 (11). pp. 2600-2604. ISSN 0163-3864, DOI https://doi.org/10.1021/acs.jnatprod.8b00749.
Full text not available from this repository.Abstract
Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | alkaloid; antineoplastic agent; bisleuconothine B; bisleuconothine C; bisleuconothine D; unclassified drug |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Apr 2019 01:36 |
| Last Modified: | 02 Sep 2021 04:24 |
| URI: | http://eprints.um.edu.my/id/eprint/21094 |
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