The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells

Phan, Chia Wei and Sabaratnam, Vikineswary and Yong, Wai Kuan and Abd Malek, Sri Nurestri (2018) The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells. Natural Product Research, 32 (10). pp. 1229-1233. ISSN 1478-6419

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Official URL: https://doi.org/10.1080/14786419.2017.1331226

Abstract

Chalcones are a group of compounds widely distributed in plant kingdom. The aim of this study was to assess the neurite outgrowth stimulatory activity of selected chalcones, namely helichrysetin, xanthohumol and flavokawin-C. Using adherent rat pheochromocytoma (PC12 Adh) cells, the chalcones were subjected to neurite outgrowth assay and the extracellular nerve growth factor (NGF) levels were determined. Xanthohumol (10 μg/mL) displayed the highest (p < 0.05) percentage of neurite-bearing PC12 Adh cells and the highest (p < 0.05) NGF level in the culture medium of xanthohumol-treated cells. While, helichrysetin induced a moderately high numbers of neurite-bearing cells, flavokawin-C did not stimulate neurite outgrowth. This work supports the potential use of xanthohumol as a potential neuroactive compound to stimulate neurite outgrowth.

Item Type: Article
Uncontrolled Keywords: Chalcone; helichrysetin; xanthohumol; flavokawin-C; PC12; neurite outgrowth
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
R Medicine
Divisions: Faculty of Medicine
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Apr 2019 02:25
Last Modified: 19 Apr 2019 02:25
URI: http://eprints.um.edu.my/id/eprint/21030

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