Phan, Chia Wei and Sabaratnam, Vikineswary and Yong, Wai Kuan and Abd Malek, Sri Nurestri (2018) The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells. Natural Product Research, 32 (10). pp. 1229-1233. ISSN 1478-6419, DOI https://doi.org/10.1080/14786419.2017.1331226.
Full text not available from this repository.Abstract
Chalcones are a group of compounds widely distributed in plant kingdom. The aim of this study was to assess the neurite outgrowth stimulatory activity of selected chalcones, namely helichrysetin, xanthohumol and flavokawin-C. Using adherent rat pheochromocytoma (PC12 Adh) cells, the chalcones were subjected to neurite outgrowth assay and the extracellular nerve growth factor (NGF) levels were determined. Xanthohumol (10 μg/mL) displayed the highest (p < 0.05) percentage of neurite-bearing PC12 Adh cells and the highest (p < 0.05) NGF level in the culture medium of xanthohumol-treated cells. While, helichrysetin induced a moderately high numbers of neurite-bearing cells, flavokawin-C did not stimulate neurite outgrowth. This work supports the potential use of xanthohumol as a potential neuroactive compound to stimulate neurite outgrowth.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya High Impact Research MoE grant number UM.C/625/1/HIR/MoE/SC/02 |
| Uncontrolled Keywords: | Chalcone; helichrysetin; xanthohumol; flavokawin-C; PC12; neurite outgrowth |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history R Medicine |
| Divisions: | Faculty of Medicine Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 19 Apr 2019 02:25 |
| Last Modified: | 19 Apr 2019 02:25 |
| URI: | http://eprints.um.edu.my/id/eprint/21030 |
Actions (login required)
 |
View Item |
