Yazdi, Alireza Rahimnejad and Torkan, Lawrence and Stone, Wendy and Towler, Mark Robert (2017) The impact of gallium content on degradation, bioactivity, and antibacterial potency of zinc borate bioactive glass. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106 (1). pp. 367-376. ISSN 1552-4973, DOI https://doi.org/10.1002/jbm.b.33856.
Full text not available from this repository.Abstract
Zinc borate glasses with increasing gallium content (0, 2.5, 5, 10, and 15 Wt % Ga) were synthesized and their degradation, bioactivity in simulated body fluid (SBF), and antibacterial properties were investigated. ICP measurements showed that increased gallium content in the glass resulted in increased gallium ion release and decreased release of other ions. Degradability declined with the addition of gallium, indicating the formation of more symmetric BO3 units with three bridging oxygens and asymmetric BO3 units with two bridging oxygens in the glass network as the gallium content in the series increased. The formation of amorphous CaP on the glass surface after 24 h of incubation in SBF was confirmed by SEM, XRD, and FTIR analyses. Finally, antibacterial evaluation of the glasses using the agar disc-diffusion method demonstrated that the addition of gallium increased the antibacterial potency of the glasses against P. aeruginosa (Gram-negative) while decreasing it against S. epidermidis (Gram-positive); considering the ion release trends, this indicates that the gallium ion is responsible for the glasses’ antibacterial behavior against P. aeruginosa while the zinc ion controls the antibacterial activity against S. epidermidis. The statistical significance of the observed trends in the measurements were confirmed by applying the Kruskal-Wallis H Test.
| Item Type: | Article |
|---|---|
| Funders: | Collaborative Health Research Project (#315694-DAN) |
| Uncontrolled Keywords: | antibacterial; borate glass; degradation; gallium; hydroxyapatite; zinc |
| Subjects: | Q Science > QD Chemistry R Medicine |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Apr 2019 01:25 |
| Last Modified: | 18 Apr 2019 01:25 |
| URI: | http://eprints.um.edu.my/id/eprint/20984 |
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