Rahman, Mohammad Azizur and Abdullah, Noorlidah and Aminudin, Norhaniza (2018) Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences, 25 (8). pp. 1515-1523. ISSN 1319-562X, DOI https://doi.org/10.1016/j.sjbs.2016.01.021.
Full text not available from this repository.Abstract
Mushrooms have been highly regarded as possessing enormous nutritive and medicinal values. In the present study, we evaluated the anti-oxidative and anti-atherosclerotic potential of shiitake mushroom (Lentinula edodes) using its solvent–solvent partitioned fractions that consisted of methanol:dichloromethane (M:DCM), hexane (HEX), dichloromethane (DCM), ethyl acetate (EA) and aqueous residue (AQ). The hexane fraction (1 mg/mL) mostly scavenged (67.38%, IC50 0.55 mg/mL) the 2,2-diphenyl-1-picryl hydrazyl (DPPH) free radical, contained the highest reducing capacity (60.16 mg gallic acid equivalents/g fraction), and most potently inhibited lipid peroxidation (67.07%), low density lipo-protein oxidation and the activity of 3-hydroxy 3-methyl glutaryl co-enzyme A reductase (HMGR). GC–MS analyses of the hexane fraction identified α-tocopherol (vitamin E), oleic acid, linoleic acid, ergosterol and butyric acid as the bio-functional components present in L. edodes. Our findings suggest that L. edodes possesses anti-atherosclerotic bio-functionality that can be applied as functional food-based therapeutics against cardiovascular diseases.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya, Malaysia: UMRG Grant (RP014D-13AFR), IPPP Grant (PG109-2013B), Bright Sparks Unit, University of Malaya |
| Uncontrolled Keywords: | Cardiovascular disease; Functional food; HMG Co-A reductase; Lipid peroxidation; Low density lipoprotein |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Apr 2019 09:08 |
| Last Modified: | 17 Apr 2019 09:08 |
| URI: | http://eprints.um.edu.my/id/eprint/20980 |
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