Exacerbated symptoms in Blastocystis sp.-infected patients treated with metronidazole: two case studies

Rajamanikam, Arutchelvan and Kumar, Suresh and Samudi, Chandramathi and Kudva, Madhav (2018) Exacerbated symptoms in Blastocystis sp.-infected patients treated with metronidazole: two case studies. Parasitology Research, 117 (8). pp. 2585-2590. ISSN 0932-0113

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Official URL: https://doi.org/10.1007/s00436-018-5948-x

Abstract

Blastocystis sp. is a gastrointestinal (GI) protozoan parasite reported to cause non-specific GI symptoms including diarrhea, flatulence, abdominal pain, and nausea. Complete eradication of Blastocystis sp. is rather challenging even with the drug of choice, i.e., metronidazole. Here, we report on two Blastocystis sp.-infected individuals, who presented increased parasite load and exacerbated symptoms upon treatment with the usual recommended dosage and regime of metronidazole. The two studies uniquely demonstrate for the first time a cyst count as high as fivefold more than the original cyst count before treatment and show an exacerbation of GI symptoms despite treatment. The study provides additional support in recognizing metronidazole resistance in Blastocystis sp. and its consequences towards the pathogenicity of the parasite.

Item Type: Article
Uncontrolled Keywords: Blastocystis sp; Cysts; Exacerbation of symptoms; Metronidazole; Subtypes
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Apr 2019 03:47
Last Modified: 17 Apr 2019 03:47
URI: http://eprints.um.edu.my/id/eprint/20947

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