Styryl lactones from roots and barks goniothalamus lanceolatus

Rasol, Nurulfazlina Edayah and Ahmad, Fasihuddin Badruddin and Mai, Chun Wai and Bihud, Nur Vicky and Abdullah, Fauziah Hanum and Awang, Khalijah and Ismail, Nor Hadiani (2018) Styryl lactones from roots and barks goniothalamus lanceolatus. Natural Product Communications, 13 (12). pp. 1575-1578. ISSN 1934-578X

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Official URL: https://journals.sagepub.com/doi/pdf/10.1177/19345...

Abstract

A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8S-goniodiol-7-monoacetate 5, 6S,7S,8S-goniodiol-8-monoacetate 6, goniofupyrone B 7, deoxygoniopypyrone B 8 and 1S,5S,7R,8S,3-endo,7-endo-(+)-8-epi-9-deoxygoniopypyrone acetate 9, along with six known styryl lactones (1, 10-15) were also isolated and characterized. 6S-goniothalamin 1 is reported for the first time from a Goniothalamus species. 1, 11 and 12 showed cytotoxic activity against human colon and lung cancer cell lines with IC 50 values ranging from 2.38-7.59 µM.

Item Type: Article
Uncontrolled Keywords: Goniothalamus lanceolatus; Styryl lactones; Cytotoxicity
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Apr 2019 01:41
Last Modified: 16 Apr 2019 01:41
URI: http://eprints.um.edu.my/id/eprint/20912

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