Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population

Riazalhosseini, Behnaz and Mohamed, Zahurin and Apalasamy, Yamunah Devi and Shafie, Noor Shafila and Mohamed, Rosmawati (2018) Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population. Biomedical Reports, 9 (3). pp. 213-220. ISSN 2049-9434

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Official URL: https://doi.org/10.3892/br.2018.1126

Abstract

Interleukin-6 (IL-6) is a cytokine with a critical role in regulating the immune response to infectious disease. Studies have indicated that polymorphisms in the IL-6 gene may be linked to hepatitis B virus (HBV) infection. The purpose of the present study was to examine the association among IL-6 SNPs and haplotypes with HBV infection risk in a Malaysian population. A total of 1,246 Malaysian subjects with and without chronic hepatitis B were recruited for this study. Three IL-6 polymorphisms (rs2069837, rs1800796 and rs2066992) were genotyped using a Sequenom MassARRAY® platform. The results suggested that GC and CC genotypes of rs1800796 as well as GT and TT genotypes of rs2066992 were associated with protection against HBV infection (P<0.001). Furthermore, haplotypes GG and CT exhibited a significant association with protection against HBV (P=0.003 and =0.005, respectively); and haplotypes GG and CT exhibited a signifi­cant association with clearance of HBV infection (P=0.035 and =0.037, respectively). The present study indicates that two IL-6 SNPs (rs1800796 and rs2066992) are associated with clearance of chronic HBV or protection against HBV infection at allelic, genotypic and haplotypic levels.

Item Type: Article
Uncontrolled Keywords: Hepatitis B virus; Infection resolution; Interleukin-6 gene; Polymorphism; Protective allele
Subjects: H Social Sciences > HC Economic History and Conditions
R Medicine
Divisions: Faculty of Economics & Administration
Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 10 Apr 2019 07:43
Last Modified: 10 Apr 2019 07:43
URI: http://eprints.um.edu.my/id/eprint/20892

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