In vitro antioxidant and in vivo xanthine oxidase inhibitory activities of Pandanus amaryllifolius in potassium oxonate-induced hyperuricemic rats

Shukor, Nur Afira Ahmad and Ablat, Abdulwali and Muhamad, Nur Airina and Mohamad, Jamaludin (2018) In vitro antioxidant and in vivo xanthine oxidase inhibitory activities of Pandanus amaryllifolius in potassium oxonate-induced hyperuricemic rats. International Journal of Food Science & Technology, 53 (6). pp. 1476-1485. ISSN 0950-5423

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Official URL: https://doi.org/10.1111/ijfs.13728

Abstract

Xanthine oxidase (XO) plays an important role in the regulation of uric acid and prevents it from being overproduced as in hyperuricemia disease. The combined effects of antioxidant and xanthine oxidase inhibitor would become a promising approach for hyperuricemia treatment. In this research, the antioxidant and xanthine oxidase inhibitory activities of Pandanus amaryllifolius leaf were evaluated. The leaf water extract (PA-W) showed highest total phenols, and petroleum ether extract (PA-PE) showed highest total flavonoids contents. The antioxidant activity of DPPH, metal chelating and hydrogen peroxide was highest in PA-W extract. The treatment of PA-W extract at 1000 mg kg−1 body weight in potassium oxonate-induced hyperuricemic rats showed significant (P < 0.001) decrease in serum uric acid level by 85% and XO activity by 64%, respectively, as compared to the hyperuricemic rats. In conclusion, the P. amaryllifolius possess the dual effect of antioxidant and XO inhibition as potential therapeutic agents in the hyperuricemia treatment.

Item Type: Article
Uncontrolled Keywords: Flavonoids; hyperuricemia; Pandanus amaryllifolius; phenols; xanthine oxidase
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Mar 2019 01:23
Last Modified: 13 Mar 2019 01:23
URI: http://eprints.um.edu.my/id/eprint/20669

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