Subramaniam, Prasanna and Jabar, Kartini Abdul and Kee, Boon Pin and Chong, Chun Wie and Nathan, Anna Marie and De Bruyne, Jessie Anne and Thavagnanam, Surendran and Chua, Kek Heng and Md Yusof, Mohd Yasim and Teh, Cindy Shuan Ju (2018) Serotypes & penicillin susceptibility of Streptococcus pneumoniae isolated from children admitted to a tertiary teaching hospital in Malaysia. Indian Journal of Medical Research, 148 (2). pp. 225-231. ISSN 0971-5916, DOI https://doi.org/10.4103/ijmr.IJMR_1987_16.
Full text not available from this repository.Abstract
Background & objectives: Streptococcus pneumoniae (pneumococcus) is a highly invasive extracellular pathogen that causes diseases such as pneumonia, otitis media and meningitis. This study was undertaken to determine the serotype diversity and penicillin susceptibility of S. pneumoniae isolated from paediatric patients in a tertiary teaching hospital in Malaysia. Methods: A total of 125 clinical isolates collected from January 2013 to May 2015 were serotyped using seven sequential multiplex polymerase chain reactions. The susceptibility of these isolates to penicillin was also investigated. Results: Serotypes detected among the isolates were serotypes 3, 6A/B, 6C, 11/A/D/F, 15A/F, 19A, 19F, 23A, 23F, 34. Serotypes 19F and 6A/B were the most prevalent serotypes detected. Most of the S. pneumoniae were isolated from nasopharyngeal samples of children below five years of age. Majority of the isolates were penicillin susceptible. Only 5.6 per cent of the isolates were non-susceptible to penicillin, mostly of serotype 19F. Interpretation & conclusions: Our study revealed the distribution of various serotypes in S. pneumoniae isolates obtained from children in a teaching hospital at Kuala Lumpur, Malaysia and decreasing rates of penicillin resistance among them. The shifts in serotypes and susceptibility to penicillin from time to time have been observed. Continuous monitoring and surveillance are pivotal for better infection control and management of pneumococcal infections among children.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Research Grant (UMRG: RP026B-14HTM), University of Malaya High Impact Research (grant number: H-50001-00-A000025) |
| Uncontrolled Keywords: | Capsular typing; pneumococcus; pneumonia; sequential multiplex PCR; serotyping; Streptococcus pneumoniae |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 05 Mar 2019 02:49 |
| Last Modified: | 05 Mar 2019 02:49 |
| URI: | http://eprints.um.edu.my/id/eprint/20606 |
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