Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression

Taha, Hairin and Arya, Aditya and Khan, Ataul Karim and Shahid, Nayiar and Noordin, Mohammed Ibrahim and Mohan, Syam (2018) Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression. Journal of Applied Biomedicine, 16 (4). pp. 263-273. ISSN 1214-021X

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Official URL: https://doi.org/10.1016/j.jab.2018.05.004

Abstract

Pseuduvaria macrophylla (Family: Annonaceae) is commonly used as medicinal plant in Malaysia. A recent study with the Pseuduvaria species showed antioxidant and antidiabetic effects. This study aimed to ascertain antidiabetic potential of methanolic extract of Pseuduvaria macrophylla bark (PM) using streptozotocin-nicotinamide induced diabetic rat models. Various phytochemical and biochemical properties of the plant have been evaluated. The results showed that the extract has potentially normalized the elevated blood glucose levels by upregulating the insulin and C-peptide levels and alleviated oxidative stress by improving glutathione (GSH) and reducing lipid peroxidation (LPO) in the diabetic rats. In addition, PM has drastically downregulated the levels of pro-inflammatory cytokines and transforming growth factor beta-1 (TGF-β1). Histopathological examination of the pancreas in PM treated diabetic rats showed significant recovery of the pancreatic structural degeneration and thus reflected the protective role of PM against peroxidation damage by a rise in insulin level as evidenced by the immunohistochemistry study. The improved expressions of GLUT-1, GLUT-2 and GLUT-4 further confirmed the restoration of β-cell mass by PM. Interestingly, the findings demonstrated the antioxidant, anti-inflammatory and antihyperglycemic potential of PM which may provide future lead for the management of type-2 diabetes.

Item Type: Article
Additional Information: Ataul Karim Khan & Nayiar Shahid. Doctoral Degree (phd). Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Pseuduvaria macrophylla; Type 2 diabetes; GLUT; Phenolic; Insulin; Glucose transporter
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 04 Mar 2019 07:03
Last Modified: 04 Mar 2019 07:03
URI: http://eprints.um.edu.my/id/eprint/20582

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