Tan, Kim Kee and Nellis, S. and Zulkifle, Nurul Izzani and Sulaiman, Syuhaida and AbuBakar, Sazaly (2018) Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity. Epidemiology and Infection, 146 (13). pp. 1635-1641. ISSN 0950-2688, DOI https://doi.org/10.1017/S0950268818001425.
Full text not available from this repository.Abstract
Dengue virus type 3 genotype III (DENV-3/III) is widely distributed in most dengue-endemic regions. It emerged in Malaysia in 2008 and autochthonously spread in the midst of endemic DENV-3/I circulation. The spread, however, was limited and the virus did not cause any major outbreak. Spatiotemporal distribution study of DENV-3 over the period between 2005 and 2011 revealed that dengue cases involving DENV-3/III occurred mostly in areas without pre-existing circulating DENV-3. Neutralisation assays performed using sera of patients with the respective infection showed that the DENV-3/III viruses can be effectively neutralised by sera of patients with DENV-3 infection (50% foci reduction neutralisation titres (FRNT50) > 1300). Sera of patients with DENV-1 infection (FRNT50 â 190), but not sera of patients with DENV-2 infection (FRNT50 â 50), were also able to neutralise the virus. These findings highlight the possibility that the pre-existing homotypic DENV-3 and the cross-reacting heterotypic DENV-1 antibody responses could play a role in mitigating a major outbreak involving DENV-3/III in the Klang Valley, Malaysia.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Arbovirus; dengue virus; immunity; infectious disease; Malaysia |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Feb 2019 05:21 |
| Last Modified: | 28 Feb 2019 05:21 |
| URI: | http://eprints.um.edu.my/id/eprint/20538 |
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