Yaacob, Syed Fariq Fathullah Syed and Kamboh, Muhammad Afzal and Wan Ibrahim, Wan Aini and Mohamad, Sharifah (2018) New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples. Royal Society Open Science, 5 (7). p. 171311. ISSN 2054-5703, DOI https://doi.org/10.1098/rsos.171311.
Full text not available from this repository.Abstract
A magnetic solid-phase extraction (MSPE)procedure on the newly synthesized magnetic β-cyclodextrin functionalized with toluene diisocyanate (TDI)as a linker and further modified with bio-polymeric spores of sporopollenin (MSp-TDI-βCD), was developed for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs), namely, indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP)and fenoprofen (FNP)from water samples prior to their HPLC-DAD determination. The newly synthesized MSp-TDI-βCD was comprehensibly characterized using FT-IR, XRD, SEM-EDX, BET and VSM analyses. The separation of selected NSAIDs on MSp-TDI-βCD from aqueous solution was simply achieved by applying an external magnetic field via a permanent magnet. The MSPE parameters affecting extraction performance, i.e. sorbent dosage, sample volume, extraction and desorption time, type of organic eluent and volume and solution pH were investigated and optimized. The proposed method showed linear range between 0.5 and 500 ng ml-1, low limit of detection at S/N=3 (0.16-0.37 ng ml-1)and limit of quantification at S/N=10 (0.53-1.22 ng ml-1). The inter-day (n=15)and intra-day (n=5)precision for the proposed methods given by relative standard deviation (RSD%)was in the range of 2.5-4.0 and 2.1-5.5, respectively. The extraction recoveries of NSAIDs from environmental samples (tap, drinking and river water)ranged from 92.5% to 123.6%, with satisfactory precision (RSD% less than 12.4%).
| Item Type: | Article |
|---|---|
| Funders: | University Malaya Research Grants (Project No. PG046-2015A), Ministry of Higher Education Malaysia, University Malaya Research Grants (Project No. RP020A-16SUS), University Malaya Research Grant–Frontier Science (Project No. RG381-17AFR) |
| Uncontrolled Keywords: | Magnetic nanoparticles; Magnetic solid-phase extraction; NSAIDs; Sporopollenin; β-cyclodextrin |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Feb 2019 08:55 |
| Last Modified: | 15 Feb 2019 08:55 |
| URI: | http://eprints.um.edu.my/id/eprint/20343 |
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