Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil

Zahed, Fatemeh Modarres and Hatamluyi, Behnaz and Lorestani, Farnaz and Es’haghi, Zarrin (2018) Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil. Journal of Pharmaceutical and Biomedical Analysis, 161. pp. 12-19. ISSN 0731-7085

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Official URL: https://doi.org/10.1016/j.jpba.2018.08.004

Abstract

A highly efficient electrochemical sensor for the analysis of anticancer drug 5-fluorouracil (5-FU), is fabricated based on silver nanoparticles-polyaniline nanotube (AgNPs@PANINTs). AgNPs@PANINTs nanocomposite has been synthesized by a simple one-step method. Synthesized AgNPs@PANINTs nanocomposite was studied by Fourier transform infrared spectrometry, Scanning Electron Microscopy and Energy Dispersive X-ray. The fabricated PANINTs@AgNPs PGE was applied to the electrochemical sensing of 5-FU. Cyclic voltammetry and differential pulse voltammetry experiments illustrated high electro activity for the AgNPs@PANINTs nanocomposite. The study was explored using the Taguchi experimental design method. Electrochemical measurements using differential pulse voltammetry showed a wide linear relationship between 5-FU concentration and peak height within the range 1.0–300.0 μM with a low detection limit (0.06 μM). Also, the fabricated sensor showed excellent selectivity in the presence of two anticancer drugs and a number of other interfering compounds. The as-prepared sensor showed to be a promising device for a simple, rapid, and direct analysis of 5-FU.

Item Type: Article
Uncontrolled Keywords: Silver nanoparticles; Polyaniline nanotubes; 5-Fluorouracil; Differential pulse voltammetry
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 Jan 2019 02:01
Last Modified: 30 Jan 2019 02:01
URI: http://eprints.um.edu.my/id/eprint/20217

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