Zahed, Fatemeh Modarres and Hatamluyi, Behnaz and Lorestani, Farnaz and Es’haghi, Zarrin (2018) Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil. Journal of Pharmaceutical and Biomedical Analysis, 161. pp. 12-19. ISSN 0731-7085, DOI https://doi.org/10.1016/j.jpba.2018.08.004.
Full text not available from this repository.Abstract
A highly efficient electrochemical sensor for the analysis of anticancer drug 5-fluorouracil (5-FU), is fabricated based on silver nanoparticles-polyaniline nanotube (AgNPs@PANINTs). AgNPs@PANINTs nanocomposite has been synthesized by a simple one-step method. Synthesized AgNPs@PANINTs nanocomposite was studied by Fourier transform infrared spectrometry, Scanning Electron Microscopy and Energy Dispersive X-ray. The fabricated PANINTs@AgNPs PGE was applied to the electrochemical sensing of 5-FU. Cyclic voltammetry and differential pulse voltammetry experiments illustrated high electro activity for the AgNPs@PANINTs nanocomposite. The study was explored using the Taguchi experimental design method. Electrochemical measurements using differential pulse voltammetry showed a wide linear relationship between 5-FU concentration and peak height within the range 1.0–300.0 μM with a low detection limit (0.06 μM). Also, the fabricated sensor showed excellent selectivity in the presence of two anticancer drugs and a number of other interfering compounds. The as-prepared sensor showed to be a promising device for a simple, rapid, and direct analysis of 5-FU.
| Item Type: | Article |
|---|---|
| Funders: | Frontier Research Grant (FG030-17AFR) and University Malaya Center for Ionic Liquids (UMCiL) |
| Uncontrolled Keywords: | Silver nanoparticles; Polyaniline nanotubes; 5-Fluorouracil; Differential pulse voltammetry |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Jan 2019 02:01 |
| Last Modified: | 30 Jan 2019 02:01 |
| URI: | http://eprints.um.edu.my/id/eprint/20217 |
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