Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity

Obaid Aldulaimi, Ahmed Kareem and Abdul Azziz, Saripah Salbiah Syed and Bakri, Yuhanis Mhd and Nafiah, Mohd Azlan and Aowda, Saadon Abdulla and Awang, Khalijah and Litaudon, Marc (2019) Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity. Phytochemistry Letters, 29. pp. 110-114. ISSN 1874-3900

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Official URL: https://doi.org/10.1016/j.phytol.2018.11.022

Abstract

Two new isoquinoline alkaloids, iraqiine (1) and kareemine (2), along with five known alkaloids, muniranine (3), kinabaline (4), O-methylmoschatoline (5), atherospermidine (6) and N-methylouregidione (7), were purified from the dichloromethane crude extract of Alphonsea cylindrica bark. The structures of these compounds were elucidated through extensive 1D and 2D NMR, IR and LC–MS studies and comparison with previously reported data. Compounds (1–5 and 7) were tested for their antioxidant activity using in vitro DPPH radical scavenging assay, and 1, 3 and 4 showed the highest antioxidant activities with IC50 values of 48.77 ± 1.01, 44.51 ± 1.12 and 64.28 ± 0.93 μg/ml, respectively.

Item Type: Article
Uncontrolled Keywords: Alphonsea cylindrical; Isoquinoline; Oxoaporphine; Bisbenzylisoquinoline; DPPH
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Jan 2019 01:06
Last Modified: 17 Jan 2019 01:06
URI: http://eprints.um.edu.my/id/eprint/20016

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