Kosiha, A. and Lo, Kong Mun and Parthiban, Chokkalingam and Elango, Kuppanagounder Pitchaimuthu (2019) Studies on the interaction of mononuclear metal(II) complexes of amino‑naphthoquinone with bio-macromolecules. Materials Science and Engineering: C, 94. pp. 778-787. ISSN 0928-4931, DOI https://doi.org/10.1016/j.msec.2018.10.021.
Full text not available from this repository.Abstract
Three metal(II) complexes [CoLCl2], [CuLCl2] and [ZnL2Cl2] {L = 2‑chloro‑3‑((3‑dimethylamino)propylamino)naphthalene‑1,4‑dione} have been synthesized and characterized using analytical, thermal and spectral techniques (FT-IR, UV–Vis, ESR and ESI-MS). The structure of the L has been confirmed by single crystal XRD study. The complexes show good binding propensity to bovine serum albumin (BSA) having relatively higher binding constant values (104 M−1) than the ligand. Fluorescence spectral studies indicate that [CoLCl2] binds relatively stronger with CT DNA through intercalative mode, exhibiting higher binding constant (2.22 × 105 M−1). Agarose gel electrophoresis run on plasmid DNA (pUC18) prove that all the complexes showed efficient DNA cleavage via hydroxyl radical mechanism. The complexes were identified as potent anticancer agents against two human cancer cell lines (MCF7 and A549) by comparing with cisplatin. Co(II) complex demonstrated greater cytotoxicity against MCF7 and A549 cells with IC50 values at 19 and 22 μM, respectively.
| Item Type: | Article |
|---|---|
| Funders: | University Grants Commission (UGC), New Delhi for UGC-BSR Fellowship, New Delhi, India [Grant No. F.4-1/2006 (BSR)/7-225/2008(BSR)/dt: 16.01.2014] |
| Uncontrolled Keywords: | Metal complex; Quinone; DNA binding; Protein binding; Cytotoxicity |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Jan 2019 07:58 |
| Last Modified: | 11 Jan 2019 07:58 |
| URI: | http://eprints.um.edu.my/id/eprint/19959 |
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