P53 Expression in Colorectal Carcinoma: The University of Malaya Medical Centre’s Experience

Goh, K.S.K.; Ong, T.A.; Peh, S.C.; Yuen, H.L.; Naicker, M. (2004) P53 Expression in Colorectal Carcinoma: The University of Malaya Medical Centre’s Experience. Medical Journal of Malaysia, 59 (4). pp. 515-521. ISSN 0300-5283

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Loss of P53 function is regarded as one of the critical steps in colorectal carcinogenesis. This study determines the P53 expression pattern of colorectal carcinoma in a cohort of 116 local patients. There was no significant relationship between overexpression of P53 with tumour stage (p=0.209, chi square test) and grade (p=0.877, chi square test). Survival analysis using Kaplan-Meier procedure did not show significant relationship between P53 positivity with overall recurrence-free and survival outcome (p=0.3322 and 0.921 respectively; log rank test). Long- term follow-up may give a better evaluation on the prognostic value of P53 overexpression in colorectal carcinoma.

Item Type: Article
  1. Goh, K.S.K.(University of Malaya)
  2. Ong, T.A.(University of Malaya)
  3. Peh, S.C.(University of Malaya)
  4. Yuen, H.L.(University of Malaya)
  5. Naicker, M.(University of Malaya)
Journal or Publication Title: Medical Journal of Malaysia
Additional Information: Universiti Malaya Medical Centre. Faculty of Medicine. Dept. of Pathology.
Uncontrolled Keywords: P53; Colorectal Carcinoma
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 11 Aug 2011 11:34
Last Modified: 20 Oct 2014 10:54
URI: http://eprints.um.edu.my/id/eprint/1983

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