Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Tan, Siow Ping and Ali, Abdul Manaf and Nafiah, Mohd Azlan and Awang, Khalijah and Ahmad, Kartini (2015) Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng. Tetrahedron, 71 (23). pp. 3946-3953. ISSN 0040-4020

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Official URL: http://dx.doi.org/10.1016/j.tet.2015.04.037

Abstract

Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2-4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay.

Item Type: Article
Uncontrolled Keywords: Carbazoles; Cytotoxicity; Murraya koenigii; MTT assay; Rutaceae
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 05 Oct 2018 05:20
Last Modified: 05 Oct 2018 05:20
URI: http://eprints.um.edu.my/id/eprint/19613

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