Faecal prevalence of extended-spectrum ß-lactamase (ESBL)-producing coliforms in a geriatric population and among haematology patients

Nurul Atifah, M.A.; Loo, H.K.C.; Wong, E.H.; Subramaniam, G.; Ho, S.E.; Selvi, P.; Parasakthi, N.; Kamarulzaman, A. (2005) Faecal prevalence of extended-spectrum ß-lactamase (ESBL)-producing coliforms in a geriatric population and among haematology patients. Malaysian Journal of Pathology, 27 (2). pp. 75-81. ISSN 0126-8635

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    Antimicrobial resistance to the extended-spectrum cephalosporins is increasingly reported worldwide. In the local setting, nosocomial infections with multi-resistant Gram-negative bacilli are not uncommon and are a growing concern. However, there is limited data on the carriage rates of such organisms in the local setting. In May 2001, a prospective study was carried out to determine the enteric carriage rates of ceftazidime-resistant Gram negative bacilli (CAZ-R GNB) among residents of nursing homes and from in-patients of the geriatric and adult haematology wards of University Malaya Medical Centre. Ceftazidime-resistant Gram-negative bacilli (CAZ-R GNB) were detected in 25 samples (30%), out of which 6 were from nursing home residents, 5 from geriatric in-patients and 14 from the haematology unit. A total of 28 CAZ-R GNB were isolated and Escherichia coli (10) and Klebsiella pneumoniae (7) were the predominant organisms. Resistance to ceftazidime in E. coli and Klebsiella was mediated by extended-spectrum beta-lactamases (ESBLs). Although the majority of the CAZ-R GNB were from patients in the haematology ward, the six nursing home residents with CAZ-R GNB were enteric carriers of ESBL-producing coliforms. Prior exposure to antibiotics was associated with carriage of ESBL organisms and to a lesser extent, the presence of urinary catheters.

    Item Type: Article
    1. Nurul Atifah, M.A.(University of Malaya)
    2. Loo, H.K.C.(University of Malaya)
    3. Wong, E.H.(University of Malaya)
    4. Subramaniam, G.(University of Malaya)
    5. Ho, S.E.(University of Malaya)
    6. Selvi, P.(University of Malaya)
    7. Parasakthi, N.(University of Malaya)
    8. Kamarulzaman, A.(University of Malaya)
    Journal or Publication Title: Malaysian Journal of Pathology
    Additional Information: University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
    Uncontrolled Keywords: ESBL; Geriatric Population; Gram Negative Bacilli
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Mr. Faizal Hamzah
    Date Deposited: 09 Aug 2011 08:54
    Last Modified: 20 Oct 2014 12:05
    URI: http://eprints.um.edu.my/id/eprint/1960

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