Faecal prevalence of extended-spectrum ß-lactamase (ESBL)-producing coliforms in a geriatric population and among haematology patients

Nurul Atifah , M.A.; Loo, H.K.C.; Wong, E.H.; Subramaniam, G.; Ho, S.E.; Selvi, P.; Parasakthi , N.; Kamarulzaman , A. (2005) Faecal prevalence of extended-spectrum ß-lactamase (ESBL)-producing coliforms in a geriatric population and among haematology patients. Malaysian Journal of Pathology, 27 (2). pp. 75-81. ISSN 0126-8635

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    Abstract

    Antimicrobial resistance to the extended-spectrum cephalosporins is increasingly reported worldwide. In the local setting, nosocomial infections with multi-resistant Gram-negative bacilli are not uncommon and are a growing concern. However, there is limited data on the carriage rates of such organisms in the local setting. In May 2001, a prospective study was carried out to determine the enteric carriage rates of ceftazidime-resistant Gram negative bacilli (CAZ-R GNB) among residents of nursing homes and from in-patients of the geriatric and adult haematology wards of University Malaya Medical Centre. Ceftazidime-resistant Gram-negative bacilli (CAZ-R GNB) were detected in 25 samples (30%), out of which 6 were from nursing home residents, 5 from geriatric in-patients and 14 from the haematology unit. A total of 28 CAZ-R GNB were isolated and Escherichia coli (10) and Klebsiella pneumoniae (7) were the predominant organisms. Resistance to ceftazidime in E. coli and Klebsiella was mediated by extended-spectrum beta-lactamases (ESBLs). Although the majority of the CAZ-R GNB were from patients in the haematology ward, the six nursing home residents with CAZ-R GNB were enteric carriers of ESBL-producing coliforms. Prior exposure to antibiotics was associated with carriage of ESBL organisms and to a lesser extent, the presence of urinary catheters.

    Item Type: Article
    Creators:
    1. Nurul Atifah , M.A.(University of Malaya)
    2. Loo, H.K.C.(University of Malaya)
    3. Wong, E.H.(University of Malaya)
    4. Subramaniam, G.(University of Malaya)
    5. Ho, S.E.(University of Malaya)
    6. Selvi, P.(University of Malaya)
    7. Parasakthi , N.(University of Malaya)
    8. Kamarulzaman , A.(University of Malaya)
    Journal or Publication Title: Malaysian Journal of Pathology
    Additional Information: University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
    Uncontrolled Keywords: ESBL; Geriatric Population; Gram Negative Bacilli
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Mr. Faizal Hamzah
    Date Deposited: 09 Aug 2011 08:54
    Last Modified: 09 Aug 2011 08:54
    URI: http://eprints.um.edu.my/id/eprint/1960

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