Tang, Esther Lai-Har and Rajarajeswaran, Jayakumar and Fung, Shin Yee and Kanthimathi, M S Subramaniam (2015) Petroselinum crispumhas antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells. Journal of the Science of Food and Agriculture, 95 (13). pp. 2763-2771. ISSN 0022-5142, DOI https://doi.org/10.1002/jsfa.7078.
Full text not available from this repository.Abstract
BACKGROUND: Petroselinum crispum (English parsley) is a common herb of the Apiaceae family that is cultivated throughout the world and is widely used as a seasoning condiment. Studies have shown its potential as a medicinal herb. In this study, P. crispum leaf and stem extracts were evaluated for their antioxidant properties, protection against DNA damage in normal 3T3-L1 cells, and the inhibition of proliferation and migration of the MCF-7 cells. RESULTS: The dichloromethane extract of P. crispum exhibited the highest phenolic content (42.31 ± 0.50 mg GAE g-1) and ferric reducing ability (0.360 ± 0.009 mmol g-1) of the various extractions performed. The extract showed DPPH radical scavenging activity with an IC50 value of 3310.0 ± 80.5 μg mL-1. Mouse fibroblasts (3T3-L1) pre-treated with 400 μg mL-1 of the extract showed 50.9% protection against H2O2-induced DNA damage, suggesting its potential in cancer prevention. The extract (300 μg mL-1) inhibited H2O2-induced MCF-7 cell migration by 41% ± 4%. As cell migration is necessary for metastasis of cancer cells, inhibition of migration is an indication of protection against metastasis. CONCLUSION: Petroselinum crispum has health-promoting properties with the potential to prevent oxidative stress-related diseases and can be developed into functional food.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antioxidant activity; Antiproliferative activity; DNA protection; Hydrogen peroxide; MCF-7 cell migration; Petroselinum crispum |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 05 Oct 2018 03:01 |
| Last Modified: | 21 Mar 2019 06:32 |
| URI: | http://eprints.um.edu.my/id/eprint/19599 |
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