Tang, Mei San and Poles, Jordan and Leung, Jacqueline M. and Wolff, Martin J. and Davenport, Michael and Lee, Soo Ching and Lim, Yvonne Ai Lian and Chua, Kek Heng and Loke, P'ng and Cho, Ilseung (2015) Inferred metagenomic comparison of mucosal and fecal microbiota from individuals undergoing routine screening colonoscopy reveals similar differences observed during active inflammation. Gut Microbes, 6 (1). pp. 48-56. ISSN 1949-0976, DOI https://doi.org/10.1080/19490976.2014.1000080.
Full text not available from this repository.Abstract
The mucosal microbiota lives in close proximity with the intestinal epithelium and may interact more directly with the host immune system than the luminal/fecal bacteria. The availability of nutrients in the mucus layer of the epithelium is also very different from the gut lumen environment. Inferred metagenomic analysis for microbial function of the mucosal microbiota is possible by PICRUSt. We recently found that by using this approach, actively inflamed tissue of ulcerative colitis (UC) patients have mucosal communities enriched for genes involved in lipid and amino acid metabolism, and reduced for carbohydrate and nucleotide metabolism. Here, we find that the same bacterial taxa (e.g. Acinetobacter) and predicted microbial pathways enriched in actively inflamed colitis tissue are also enriched in the mucosa of subjects undergoing routine screening colonoscopies, when compared with paired samples of luminal/fecal bacteria. These results suggest that the mucosa of healthy individuals may be a reservoir of aerotolerant microbial communities expanded during colitis.
| Item Type: | Article |
|---|---|
| Funders: | Kevin and Marsha Keating Family Foundation, UM/MoHE High Impact Research (H-20001–00-E000061) grant from University of Malaya, Grants from the National Institutes of Health (AI093811 and AI094166), Broad Medical Research Program, University of Malaya Student Grant (PV024/2011B), Grants-in-Aid of Research (G2012161472) from Sigma Xi, The Scientific Research Society, AGA-Eli and Edythe Broad Student Research Fellowship |
| Uncontrolled Keywords: | Acinetobacter; Colitis; Inflammation; Microbiome; Mucosa; Proteobacteria |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 05 Oct 2018 02:41 |
| Last Modified: | 05 Oct 2018 02:41 |
| URI: | http://eprints.um.edu.my/id/eprint/19595 |
Actions (login required)
 |
View Item |
