Ng, K.T. and Takebe, Y. and Chook, J.B. and Chow, W.Z. and Chan, Kok Gan and Al-Darraji, H.A. and Kamarulzaman, Adeeba and Tee, Kok Keng (2015) Co-infections and transmission networks of HCV, HIV-1 and HPgV among people who inject drugs. Scientific Reports, 5 (1). p. 15198. ISSN 2045-2322, DOI https://doi.org/10.1038/srep15198.
Full text not available from this repository.Abstract
Co-infections with human immunodeficiency virus type 1 (HIV-1) and human pegivirus (HPgV) are common in hepatitis C virus (HCV)-infected individuals. However, analysis on the evolutionary dynamics and transmission network profiles of these viruses among individuals with multiple infections remains limited. A total of 228 injecting drug users (IDUs), either HCV-and/or HIV-1-infected, were recruited in Kuala Lumpur, Malaysia. HCV, HIV-1 and HPgV genes were sequenced, with epidemic growth rates assessed by the Bayesian coalescent method. Based on the sequence data, mono-, dual-and triple-infection were detected in 38.8%, 40.6% and 20.6% of the subjects, respectively. Fifteen transmission networks involving HCV (subtype 1a, 1b, 3a and 3b), HIV-1 (CRF33-01B) and HPgV (genotype 2) were identified and characterized. Genealogical estimates indicated that the predominant HCV, HIV-1 and HPgV genotypes were introduced into the IDUs population through multiple sub-epidemics that emerged as early as 1950s (HCV), 1980s (HIV-1) and 1990s (HPgV). By determining the difference in divergence times between viral lineages (δtMRCA), we also showed that the frequency of viral co-transmission is low among these IDUs. Despite increased access to therapy and other harm reduction interventions, the continuous emergence and coexistence of new transmission networks suggest persistent multiple viral transmissions among IDUs.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Coinfection; Drug Users; Flavivirus Infections; Genotype; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Malaysia; Phylogeny |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 02 Oct 2018 07:04 |
| Last Modified: | 23 Dec 2019 05:56 |
| URI: | http://eprints.um.edu.my/id/eprint/19540 |
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