DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex

Vikneswaran, R. and Eltayeb, N.E. and Ramesh, S. and Yahya, R. (2015) DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex. Bulletin of the Chemical Society of Japan, 88 (8). pp. 1156-1158. ISSN 0009-2673

Full text not available from this repository.
Official URL: http://dx.doi.org/10.1246/bcsj.20150084

Abstract

A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to DNA through an intercalation mechanism.

Item Type: Article
Uncontrolled Keywords: Carboplatin; DNA interaction; HeLa cell; Intercalation mechanisms; Substituted thiophene; Thiosemicarbazone complexes; Thiosemicarbazones; Zinc complex
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Faculty of Science > Dept of Physics
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 01 Oct 2018 03:25
Last Modified: 01 Oct 2018 03:25
URI: http://eprints.um.edu.my/id/eprint/19493

Actions (login required)

View Item View Item