Vikneswaran, R. and Eltayeb, N.E. and Ramesh, S. and Yahya, R. (2015) DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex. Bulletin of the Chemical Society of Japan, 88 (8). pp. 1156-1158. ISSN 0009-2673, DOI https://doi.org/10.1246/bcsj.20150084.
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Official URL: http://dx.doi.org/10.1246/bcsj.20150084
Abstract
A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to DNA through an intercalation mechanism.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Carboplatin; DNA interaction; HeLa cell; Intercalation mechanisms; Substituted thiophene; Thiosemicarbazone complexes; Thiosemicarbazones; Zinc complex |
| Subjects: | Q Science > Q Science (General) Q Science > QC Physics Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry Faculty of Science > Department of Physics |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Oct 2018 03:25 |
| Last Modified: | 01 Oct 2018 03:25 |
| URI: | http://eprints.um.edu.my/id/eprint/19493 |
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