Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing

Wong, Wei Ru and Krupin, O. and Adikan, Faisal Rafiq Mahamd and Berini, P. (2015) Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing. Journal of Lightwave Technology (JLT), 33 (15). pp. 3234-3242. ISSN 0733-8724

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Official URL: http://dx.doi.org/10.1109/JLT.2015.2431612

Abstract

The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation αs of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂αs/∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂αs/∂a)/αs where maximizing |K| and selecting the optimal sensing length as Lopt = 1/(2αs) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓmin < 0.1 pg·mm-2 are predicted for optimal designs, and a detection limit of ΔΓmin = 4.1 pg/mm2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure.

Item Type: Article
Uncontrolled Keywords: Attenuation; Biosensor; Optimization; Sensitivity; Surface plasmon
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 28 Sep 2018 01:13
Last Modified: 11 Oct 2018 02:11
URI: http://eprints.um.edu.my/id/eprint/19436

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